Cyborg 009 is a side-scrolling shooter game exclusive to the Japanese Mega-CD. It is based on the Osamu Tezuka manga and anime Cyborg 009, about a group of people kidnapped from all over the world by the Black Ghost organization and transformed into deadly cyborgs against their will. They are rescued by a sympathetic scientist, Professor Gilmore, and now fight against Black Ghost to prevent more abductions.
The game takes plot elements from several manga arcs to construct its narrative, as well as using the character designs from the 1980 movie, Cyborg 009: Legend of the Super Galaxy, for its animated cutscenes. Unlike the Super Famicom Cyborg 009, the titular cyborg (also known as Joe) is the only playable character. Gameplay resembles other run-and-gun shooters like Contra: Hard Corps or Gunstar Heroes: 009 takes out enemies with his Super Gun, eventually fighting a boss at the end of each level.